Astaxanthin (3,3'-dihydroxy-beta, beta-carotene-4,4'-dione) yog carotenoid, cais raws li lutein, pom nyob rau hauv ntau yam kab mob thiab cov tsiaj hauv hiav txwv, thiab Ameslikas cais los ntawm lobsters los ntawm Kuhn thiab Sorensen. Nws yog cov xim muaj roj-soluble uas zoo li txiv kab ntxwv rau xim liab thiab tsis muaj vitamin A pro-activity nyob rau hauv tib neeg lub cev.
Ntuj qhov chaw ntawm astaxanthin muaj xws li algae, poov xab, salmon, trout, krill thiab crayfish. Kev lag luam astaxanthin feem ntau yog muab los ntawm Fife poov xab, liab algae thiab tshuaj synthesis. Ib qho ntawm qhov zoo tshaj plaws ntawm ntuj astaxanthin yog rainfed liab chlorella, nrog cov ntsiab lus astaxanthin txog 3.8% (los ntawm qhov hnyav qhuav), thiab cov ntses qus qus kuj yog qhov zoo ntawm astaxanthin. Kev tsim khoom hluavtaws tseem yog qhov tseem ceeb ntawm astaxanthin vim tus nqi siab ntawm kev cog qoob loo loj ntawm Rhodococcus rainieri. Kev ua haujlwm lom neeg ntawm cov khoom siv hluavtaws astaxanthin tsuas yog 50% ntawm cov astaxanthin ntuj.
Astaxanthin muaj xws li stereoisomers, geometric isomers, dawb thiab esterified cov ntaub ntawv, nrog stereoisomers (3S, 3'S) thiab (3R, 3'R) yog qhov ntau tshaj nyob rau hauv cov xwm. Rhodococcus rainieri tsim cov (3S,3'S)-isomer thiab Fife poov xab tsim cov (3R,3'R)-isomer.
Astaxanthin, qhov kub ntawm lub sijhawm
Astaxanthin yog lub hnub qub muaj nyob rau hauv cov khoom noj muaj txiaj ntsig hauv Nyij Pooj.FTA cov txheeb cais ntawm kev tshaj tawm cov khoom noj muaj txiaj ntsig hauv Nyij Pooj xyoo 2022 pom tias astaxanthin tau nyob rau qib 7 ntawm 10 cov khoom xyaw saum toj kawg nkaus ntawm kev siv ntau zaus, thiab feem ntau yog siv hauv kev noj qab haus huv ntawm cov khoom noj. kev tu tawv nqaij, kho qhov muag, kev qaug zog, thiab txhim kho kev paub txog kev ua haujlwm.
Ntawm 2022 thiab 2023 Asian Nutrition Ingredients Awards, Justgood Health's natural astaxanthin ingredient tau lees paub tias yog cov khoom xyaw zoo tshaj plaws ntawm lub xyoo rau ob xyoos sib law liag, cov khoom xyaw zoo tshaj plaws hauv kev paub txog kev ua haujlwm hauv 2022, thiab cov khoom xyaw zoo tshaj plaws hauv qhov ncauj kev zoo nkauj hauv 2023. Tsis tas li ntawd, cov khoom xyaw tau shortlisted nyob rau hauv lub Asian Nutrition Ingredients Awards - Healthy Aging Track hauv 2024.
Nyob rau hauv xyoo tas los no, kev tshawb fawb kev kawm ntawm astaxanthin kuj tau pib kub. Raws li PubMed cov ntaub ntawv, thaum ntxov li xyoo 1948, muaj kev tshawb fawb txog astaxanthin, tab sis kev saib xyuas tau qis, pib xyoo 2011, kev kawm tau pib tsom mus rau astaxanthin, nrog ntau tshaj 100 tshaj tawm ib xyoos, thiab ntau dua 200 hauv 2017, ntau dua. Ntau tshaj 300 hauv 2020, thiab ntau dua 400 hauv 2021.
Qhov chaw ntawm daim duab: PubMed
Hais txog kev ua lag luam, raws li Kev Tshawb Fawb Txog Kev Lag Luam Yav Tom Ntej, lub ntiaj teb astaxanthin kev lag luam loj yog kwv yees li $ 273.2 lab hauv 2024 thiab kwv yees kom ncav cuag $ 665.0 lab los ntawm 2034, ntawm CAGR ntawm 9.3% thaum lub sijhawm kwv yees (2024-2034. ).
Superior antioxidant muaj peev xwm
Astaxanthin tus qauv tshwj xeeb muab nws lub peev xwm antioxidant zoo. Astaxanthin muaj conjugated ob daim ntawv cog lus, hydroxyl thiab ketone pawg, thiab yog lipophilic thiab hydrophilic. Lub conjugated ob daim ntawv cog lus nyob rau hauv nruab nrab ntawm lub compound muab electrons thiab reacts nrog dawb radicals los hloov lawv mus rau hauv ntau ruaj khov khoom thiab txiav tawm dawb radical saw tshua nyob rau hauv ntau yam kab mob. Nws cov haujlwm lom neeg muaj txiaj ntsig zoo dua li lwm cov tshuaj antioxidants vim nws muaj peev xwm txuas mus rau cell membranes los ntawm sab hauv tawm.
Qhov chaw ntawm astaxanthin thiab lwm yam antioxidants hauv cell membranes
Astaxanthin exerts tseem ceeb antioxidant kev ua tsis tau tsuas yog los ntawm ncaj qha scavenging ntawm dawb radicals, tab sis kuj los ntawm kev ua kom lub cellular antioxidant tiv thaiv system los ntawm regulating lub nuclear yam erythroid 2-txog yam tseem ceeb (Nrf2) txoj kev. Astaxanthin inhibits qhov tsim ntawm ROS thiab tswj cov kev qhia ntawm oxidative stress-responsive enzymes, xws li heme oxygenase-1 (HO-1), uas yog ib qho cim ntawm oxidative stress.HO-1 yog tswj los ntawm ntau yam kev ntxhov siab-rhiab heev transcription. yam tseem ceeb, suav nrog Nrf2, uas khi rau cov tshuaj tiv thaiv antioxidant hauv thaj tsam txhawb nqa ntawm detoxification metabolism enzymes.
Tag nrho cov txiaj ntsig ntawm astaxanthin thiab kev siv
1) Txhim kho kev paub txog kev ua haujlwm
Ntau cov kev tshawb fawb tau lees paub tias astaxanthin tuaj yeem ncua lossis txhim kho kev paub tsis meej uas cuam tshuam nrog kev laus ib txwm lossis txo cov kab mob pathophysiology ntawm ntau yam kab mob neurodegenerative. Astaxanthin tuaj yeem hla cov ntshav-hlwb teeb meem, thiab kev tshawb fawb tau pom tias kev noj zaub mov astaxanthin accumulates hauv hippocampus thiab cerebral cortex ntawm nas hlwb tom qab noj ib zaug thiab rov ua dua, uas yuav cuam tshuam rau kev saib xyuas thiab txhim kho kev txawj ntse. Astaxanthin txhawb nqa cov paj hlwb rov tsim dua tshiab thiab nce cov noob qhia ntawm glial fibrillary acidic protein (GFAP), microtubule-associated protein 2 (MAP-2), hlwb-derived neurotrophic factor (BDNF), thiab kev loj hlob ntawm cov protein 43 (GAP-43), proteins uas cuam tshuam rau lub hlwb rov qab.
Justgood Health Astaxanthin Capsules, nrog Cytisine thiab Astaxanthin los ntawm Liab Algae Rainforest, ua ke los txhim kho kev txawj ntse ntawm lub hlwb.
2) Kev Tiv Thaiv Qhov Muag
Astaxanthin muaj cov tshuaj tua kab mob antioxidant uas neutralizes oxygen dawb radical molecules thiab muab kev tiv thaiv rau lub qhov muag. Astaxanthin ua haujlwm sib koom ua ke nrog lwm cov carotenoids uas txhawb kev noj qab haus huv ntawm qhov muag, tshwj xeeb tshaj yog lutein thiab zeaxanthin. Tsis tas li ntawd, astaxanthin nce tus nqi ntawm cov ntshav ntws mus rau lub qhov muag, tso cai rau cov ntshav kom reoxygenate lub retina thiab cov ntaub so ntswg qhov muag. Cov kev tshawb fawb tau pom tias astaxanthin, ua ke nrog lwm cov carotenoids, tiv thaiv lub qhov muag ntawm kev puas tsuaj thoob plaws hnub ci spectrum. Tsis tas li ntawd, astaxanthin pab txo qhov muag tsis xis nyob thiab pom kev qaug zog.
Justgood Health Blue Light Protection Softgels, Cov khoom xyaw tseem ceeb: lutein, zeaxanthin, astaxanthin.
3) Kev tu tawv nqaij
Oxidative kev nyuaj siab yog ib qho tseem ceeb ua rau tib neeg cov tawv nqaij laus thiab dermal puas. Lub mechanism ntawm ob qho tib si intrinsic (chronological) thiab extrinsic (lub teeb) aging yog zus tau tej cov ROS, intrinsically los ntawm oxidative metabolism, thiab extrinsically los ntawm raug rau lub hnub lub ultraviolet (UV) rays. Oxidative txheej xwm nyob rau hauv daim tawv nqaij laus muaj xws li DNA puas, inflammatory teb, txo cov antioxidants, thiab zus tau tej cov matrix metalloproteinases (MMPs) uas degrade collagen thiab elastin nyob rau hauv lub dermis.
Astaxanthin tuaj yeem tiv thaiv dawb radical-induced oxidative puas tsuaj thiab induction ntawm MMP-1 hauv daim tawv nqaij tom qab UV raug. Cov kev tshawb fawb tau pom tias astaxanthin los ntawm Erythrocystis rainbowensis tuaj yeem ua rau cov ntsiab lus collagen ntxiv los ntawm inhibiting kev qhia ntawm MMP-1 thiab MMP-3 hauv tib neeg dermal fibroblasts. Tsis tas li ntawd, astaxanthin txo qis UV-induced DNA puas thiab txhim kho DNA hauv hlwb raug UV hluav taws xob.
Tam sim no Justgood Health tab tom ua ntau txoj kev tshawb fawb, suav nrog cov nas tsis muaj plaub hau thiab kev sim tib neeg, txhua tus tau pom tias astaxanthin txo UV kev puas tsuaj rau cov txheej txheej ntawm daim tawv nqaij, uas ua rau pom cov tsos mob ntawm daim tawv nqaij laus, xws li dryness, sagging tawv nqaij thiab wrinkles.
4) Khoom noj khoom haus kis las
Astaxanthin tuaj yeem ua kom lub cev rov qab ua haujlwm. Thaum tib neeg tawm dag zog los yog ua haujlwm, lub cev tsim tawm ntau ntawm ROS, uas, yog tias tsis tshem tawm hauv lub sijhawm, tuaj yeem ua rau cov nqaij ntshiv thiab cuam tshuam rau lub cev rov qab los, thaum astaxanthin lub zog antioxidant muaj peev xwm tshem tau ROS hauv lub sijhawm thiab kho cov nqaij ntshiv sai dua.
Justgood Health qhia nws cov Astaxanthin Complex tshiab, muaj ntau yam sib xyaw ntawm magnesium glycerophosphate, vitamin B6 (pyridoxine), thiab astaxanthin uas txo cov leeg mob thiab qaug zog tom qab kev tawm dag zog. Cov mis yog nyob ib ncig ntawm Justgood Health's Whole Algae Complex, uas xa cov astaxanthin ntuj uas tsis tsuas yog tiv thaiv cov leeg ntawm oxidative puas tsuaj, tab sis kuj txhim kho cov leeg nqaij thiab txhim kho kev ua kis las.
5) Kev kho mob plawv
Oxidative kev nyuaj siab thiab o ua rau lub pathophysiology ntawm atherosclerotic cardiovascular kab mob. Qhov zoo tshaj plaws antioxidant kev ua ntawm astaxanthin tuaj yeem tiv thaiv thiab txhim kho atherosclerosis.
Justgood Health Triple Strength Natural Astaxanthin Softgels pab tswj cov hlab plawv kev noj qab haus huv los ntawm kev siv natural astaxanthin los ntawm zaj sawv liab algae, cov khoom xyaw tseem ceeb uas suav nrog astaxanthin, organic virgin txiv maj phaub roj thiab ntuj tocopherols.
6) Kev tiv thaiv kab mob
Cov kab mob hauv lub cev muaj zog heev rau kev puas tsuaj dawb radical. Astaxanthin tiv thaiv lub cev tiv thaiv kab mob los ntawm kev tiv thaiv dawb radical puas. Ib txoj kev tshawb nrhiav pom tias astaxanthin hauv tib neeg lub hlwb los tsim cov tshuaj immunoglobulins, nyob rau hauv tib neeg lub cev astaxanthin supplementation rau 8 lub lis piam, astaxanthin qib hauv cov ntshav nce, T hlwb thiab B hlwb nce, DNA puas raug txo, C-reactive protein txo.
Astaxanthin softgels, raw astaxanthin, siv lub hnub ci ntuj, lava-filtered dej thiab hnub ci zog los tsim cov ntshiab thiab noj qab haus huv astaxanthin, uas tuaj yeem pab txhim kho kev tiv thaiv kab mob, tiv thaiv qhov muag thiab kev noj qab haus huv.
7) Relieve qaug zog
4-lub lim tiam randomized, ob-dig muag, placebo-tswj, ob-txoj kev crossover txoj kev tshawb pom pom tias astaxanthin txhawb kev rov qab los ntawm qhov muag pom qhov chaw nres nkoj (VDT) ua rau lub hlwb qaug zog, txo qis ntshav phosphatidylcholine hydroperoxide (PCOOH) qib thaum lub sij hawm ntawm lub hlwb thiab lub cev. kev ua si. Yog vim li cas tej zaum yuav yog cov kev ua antioxidant thiab anti-inflammatory mechanism ntawm astaxanthin.
8) Kev tiv thaiv daim siab
Astaxanthin muaj kev tiv thaiv thiab ua kom zoo rau cov teeb meem kev noj qab haus huv xws li daim siab fibrosis, daim siab ischemia-reperfusion raug mob, thiab NAFLD. Astaxanthin tuaj yeem tswj hwm ntau txoj hauv kev taw qhia, xws li txo JNK thiab ERK-1 kev ua haujlwm txhawm rau txhim kho lub siab insulin tsis kam, inhibiting PPAR-γ qhia kom txo cov rog hauv siab, thiab txo qis TGF-β1 / Smad3 qhia kom inhibit HSCs ua kom thiab daim siab fibrosis.
Cov xwm txheej ntawm cov cai hauv txhua lub tebchaws
Hauv Suav teb, astaxanthin los ntawm qhov chaw ntawm zaj sawv liab algae tuaj yeem siv los ua cov khoom noj tshiab hauv cov zaub mov dav dav (tshwj tsis yog cov zaub mov me nyuam), ntxiv rau, Tebchaws Asmeskas, Canada thiab Nyij Pooj kuj tso cai rau astaxanthin siv rau hauv cov khoom noj.
Post lub sij hawm: Dec-05-2024