Astaxanthin (3,3'-dihydroxy-beta, beta-carotene-4,4'-dione) yog ib hom carotenoid, uas yog lutein, pom muaj ntau yam kab mob me me thiab cov tsiaj hauv dej hiav txwv, thiab thawj zaug tau rho tawm los ntawm cov ntses lobster los ntawm Kuhn thiab Sorensen. Nws yog ib hom xim uas yaj tau hauv roj uas zoo li txiv kab ntxwv mus rau xim liab tob thiab tsis muaj vitamin A pro-activity hauv tib neeg lub cev.
Cov khoom siv ntuj tsim ntawm astaxanthin suav nrog algae, poov xab, ntses salmon, ntses trout, krill thiab crayfish. Cov khoom lag luam astaxanthin feem ntau yog los ntawm Fife poov xab, algae liab thiab kev tsim tshuaj lom neeg. Ib qho ntawm cov khoom zoo tshaj plaws ntawm astaxanthin ntuj yog chlorella liab uas tau los ntawm nag, nrog rau cov ntsiab lus astaxanthin ntawm kwv yees li 3.8% (los ntawm qhov hnyav qhuav), thiab ntses salmon qus kuj yog cov khoom zoo ntawm astaxanthin. Kev tsim khoom tsim tseem yog qhov tseem ceeb ntawm astaxanthin vim yog tus nqi siab ntawm kev cog qoob loo loj ntawm Rhodococcus rainieri. Cov haujlwm ntawm cov khoom tsim tawm tsuas yog 50% ntawm cov astaxanthin ntuj.
Astaxanthin muaj nyob rau hauv cov stereoisomers, geometric isomers, dawb thiab esterified daim ntawv, nrog rau stereoisomers (3S, 3'S) thiab (3R, 3'R) yog qhov muaj ntau tshaj plaws hauv xwm. Rhodococcus rainieri tsim cov (3S, 3'S)-isomer thiab Fife poov xab tsim cov (3R, 3'R)-isomer.
Astaxanthin, lub cua sov ntawm lub sijhawm no
Astaxanthin yog cov khoom xyaw tseem ceeb hauv cov khoom noj muaj txiaj ntsig hauv Nyiv Pooj. Cov ntaub ntawv ntawm FTA txog cov lus tshaj tawm txog cov khoom noj muaj txiaj ntsig hauv Nyiv Pooj xyoo 2022 pom tias astaxanthin tau raug xaiv los ua tus lej 7 ntawm 10 cov khoom xyaw saum toj kawg nkaus hauv kev siv ntau zaus, thiab feem ntau yog siv rau hauv kev kho mob ntawm kev saib xyuas tawv nqaij, kev saib xyuas qhov muag, kev txo qhov qaug zog, thiab kev txhim kho kev ua haujlwm ntawm lub hlwb.
Xyoo 2022 thiab 2023 Asian Nutritional Ingredients Awards,Justgood Health's Cov khoom xyaw astaxanthin ntuj tau raug lees paub tias yog cov khoom xyaw zoo tshaj plaws ntawm lub xyoo rau ob xyoos sib law liag, cov khoom xyaw zoo tshaj plaws hauv txoj kev ua haujlwm ntawm kev paub hauv xyoo 2022, thiab cov khoom xyaw zoo tshaj plaws hauv txoj kev zoo nkauj hauv qhov ncauj hauv xyoo 2023. Tsis tas li ntawd, cov khoom xyaw tau raug xaiv tsa hauv Asian Nutritional Ingredients Awards - Healthy Aging track hauv xyoo 2024.
Nyob rau xyoo tas los no, kev tshawb fawb txog astaxanthin kuj tau pib kub zuj zus. Raws li cov ntaub ntawv PubMed, thaum ntxov li xyoo 1948, muaj kev tshawb fawb txog astaxanthin, tab sis kev mloog tsawg, pib xyoo 2011, cov tsev kawm ntawv tau pib tsom mus rau astaxanthin, nrog ntau dua 100 phau ntawv txhua xyoo, thiab ntau dua 200 hauv xyoo 2017, ntau dua 300 hauv xyoo 2020, thiab ntau dua 400 hauv xyoo 2021.
Qhov chaw ntawm daim duab: PubMed
Hais txog kev ua lag luam, raws li Future market insights, lub ntiaj teb astaxanthin kev ua lag luam loj yog kwv yees li USD 273.2 lab hauv xyoo 2024 thiab kwv yees tias yuav ncav cuag USD 665.0 lab los ntawm xyoo 2034, ntawm CAGR ntawm 9.3% thaum lub sijhawm kwv yees (2024-2034).
Muaj peev xwm tiv thaiv kab mob zoo dua
Cov qauv tshwj xeeb ntawm Astaxanthin ua rau nws muaj peev xwm tiv thaiv kab mob zoo heev. Astaxanthin muaj cov conjugated double bonds, hydroxyl thiab ketone groups, thiab yog ob qho tib si lipophilic thiab hydrophilic. Cov conjugated double bond ntawm qhov chaw nruab nrab ntawm cov tshuaj muab cov electrons thiab reacts nrog cov free radicals los hloov lawv mus rau hauv cov khoom ruaj khov dua thiab xaus cov free radical chain reactions hauv ntau yam kab mob. Nws cov kev ua haujlwm biological zoo dua li lwm cov antioxidants vim nws muaj peev xwm txuas rau cov cell membranes los ntawm sab hauv mus rau sab nraud.
Qhov chaw ntawm astaxanthin thiab lwm yam antioxidants hauv cov cell membranes
Astaxanthin ua haujlwm tiv thaiv kab mob tseem ceeb tsis yog los ntawm kev tshem tawm cov dawb radicals ncaj qha xwb, tab sis kuj los ntawm kev ua haujlwm ntawm lub cev tiv thaiv kab mob los ntawm kev tswj hwm txoj hauv kev nuclear factor erythroid 2-related factor (Nrf2). Astaxanthin inhibits kev tsim ntawm ROS thiab tswj hwm kev qhia tawm ntawm cov enzymes oxidative stress-responsive, xws li heme oxygenase-1 (HO-1), uas yog ib qho cim ntawm kev ntxhov siab oxidative. HO-1 yog tswj hwm los ntawm ntau yam kev ntxhov siab-rhiab transcription factors, suav nrog Nrf2, uas khi rau cov ntsiab lus antioxidant-responsive hauv thaj chaw txhawb nqa ntawm cov enzymes detoxification metabolism.
Cov txiaj ntsig thiab kev siv ntawm astaxanthin tag nrho
1) Kev txhim kho ntawm kev ua haujlwm ntawm lub hlwb
Muaj ntau txoj kev tshawb fawb tau lees paub tias astaxanthin yuav ncua lossis txhim kho qhov tsis zoo ntawm kev paub txog kev laus lossis txo qhov pathophysiology ntawm ntau yam kab mob neurodegenerative. Astaxanthin tuaj yeem hla cov ntshav-lub hlwb barrier, thiab kev tshawb fawb tau qhia tias kev noj zaub mov astaxanthin sib sau ua ke hauv hippocampus thiab cerebral cortex ntawm lub hlwb nas tom qab ib zaug thiab rov ua dua, uas yuav cuam tshuam rau kev saib xyuas thiab kev txhim kho ntawm kev ua haujlwm ntawm kev paub. Astaxanthin txhawb nqa kev tsim kho tshiab ntawm cov hlab ntsha thiab ua rau cov noob caj noob ces ntawm glial fibrillary acidic protein (GFAP), microtubule-associated protein 2 (MAP-2), lub hlwb-derived neurotrophic factor (BDNF), thiab kev loj hlob-associated protein 43 (GAP-43), cov protein uas cuam tshuam rau kev rov zoo ntawm lub hlwb.
Justgood Health Astaxanthin Capsules, nrog Cytisine thiab Astaxanthin los ntawm Red Algae Rainforest, ua ke los txhim kho kev ua haujlwm ntawm lub hlwb.
2) Kev Tiv Thaiv Qhov Muag
Astaxanthin muaj cov tshuaj antioxidant uas ua rau cov pa oxygen dawb tsis muaj zog thiab tiv thaiv lub qhov muag. Astaxanthin ua haujlwm sib koom tes nrog lwm cov carotenoids uas txhawb nqa kev noj qab haus huv ntawm lub qhov muag, tshwj xeeb tshaj yog lutein thiab zeaxanthin. Tsis tas li ntawd, astaxanthin ua rau cov ntshav ntws mus rau lub qhov muag ntau dua, ua rau cov ntshav rov qab mus rau lub retina thiab cov ntaub so ntswg ntawm lub qhov muag. Cov kev tshawb fawb tau qhia tias astaxanthin, ua ke nrog lwm cov carotenoids, tiv thaiv lub qhov muag ntawm kev puas tsuaj thoob plaws lub hnub ci spectrum. Tsis tas li ntawd, astaxanthin pab txo qhov muag tsis xis nyob thiab qhov muag nkees.
Justgood Health Blue Light Protection Softgels, Cov khoom xyaw tseem ceeb: lutein, zeaxanthin, astaxanthin.
3) Kev Saib Xyuas Tawv Nqaij
Kev ntxhov siab oxidative yog ib qho tseem ceeb ua rau tib neeg daim tawv nqaij laus thiab puas tsuaj rau daim tawv nqaij. Lub tshuab ntawm kev laus sab hauv (lub sijhawm) thiab sab nraud (lub teeb) yog kev tsim cov ROS, sab hauv los ntawm kev ua haujlwm oxidative, thiab sab nraud los ntawm kev raug lub hnub lub teeb ultraviolet (UV). Cov xwm txheej oxidative hauv kev laus ntawm daim tawv nqaij suav nrog kev puas tsuaj DNA, kev mob o, kev txo qis ntawm cov antioxidants, thiab kev tsim cov matrix metalloproteinases (MMPs) uas ua rau collagen thiab elastin hauv daim tawv nqaij puas tsuaj.
Astaxanthin muaj peev xwm tiv thaiv tau qhov kev puas tsuaj oxidative los ntawm cov dawb radical thiab kev ua rau MMP-1 hauv daim tawv nqaij tom qab raug UV. Cov kev tshawb fawb tau qhia tias astaxanthin los ntawm Erythrocystis rainbowensis tuaj yeem ua rau cov collagen ntau ntxiv los ntawm kev tiv thaiv kev qhia tawm ntawm MMP-1 thiab MMP-3 hauv tib neeg cov dermal fibroblasts. Tsis tas li ntawd, astaxanthin txo qis UV-induced DNA puas tsuaj thiab ua rau DNA kho dua hauv cov hlwb raug UV hluav taws xob.
Justgood Health tam sim no tab tom ua ntau txoj kev tshawb fawb, suav nrog cov nas tsis muaj plaub thiab kev sim tib neeg, txhua yam tau qhia tias astaxanthin txo qhov kev puas tsuaj ntawm UV rau cov txheej tawv nqaij tob dua, uas ua rau muaj cov cim qhia tias daim tawv nqaij laus, xws li qhuav, tawv nqaij sagging thiab wrinkles.
4) Kev noj haus rau kev ua si
Astaxanthin tuaj yeem ua kom cov leeg kho tau sai dua tom qab ua si. Thaum tib neeg ua si lossis ua si, lub cev tsim cov ROS ntau heev, uas yog tias tsis tshem tawm raws sijhawm, tuaj yeem ua rau cov leeg puas tsuaj thiab cuam tshuam rau kev rov zoo ntawm lub cev, thaum astaxanthin lub zog antioxidant muaj zog tuaj yeem tshem tawm ROS raws sijhawm thiab kho cov leeg puas sai dua.
Justgood Health qhia txog nws cov Astaxanthin Complex tshiab, uas yog sib xyaw ua ke ntawm magnesium glycerophosphate, vitamin B6 (pyridoxine), thiab astaxanthin uas txo qhov mob nqaij thiab qaug zog tom qab ua si. Cov mis no yog nyob ib puag ncig Justgood Health's Whole Algae Complex, uas muab cov astaxanthin ntuj uas tsis yog tsuas yog tiv thaiv cov leeg nqaij ntawm kev puas tsuaj oxidative, tab sis kuj ua rau cov leeg nqaij ua haujlwm zoo dua thiab txhim kho kev ua kis las.
5) Kev Noj Qab Haus Huv ntawm Lub Plawv thiab Lub Hlwb
Kev ntxhov siab oxidative thiab kev o yog tus yam ntxwv ntawm pathophysiology ntawm atherosclerotic kab mob plawv. Cov tshuaj antioxidant zoo heev ntawm astaxanthin tuaj yeem tiv thaiv thiab txhim kho atherosclerosis.
Justgood Health Triple Strength Natural Astaxanthin Softgels pab tswj kev noj qab haus huv ntawm lub plawv los ntawm kev siv cov astaxanthin ntuj uas tau los ntawm cov algae liab xim av, cov khoom xyaw tseem ceeb suav nrog astaxanthin, roj txiv maj phaub organic thiab cov tocopherols ntuj.
6) Kev Tswj Xyuas Kev Tiv Thaiv Kab Mob
Cov qe ntshav ntawm lub cev tiv thaiv kab mob muaj kev cuam tshuam zoo rau kev puas tsuaj ntawm cov dawb radical. Astaxanthin tiv thaiv lub cev tiv thaiv kab mob los ntawm kev tiv thaiv kev puas tsuaj ntawm cov dawb radical. Ib txoj kev tshawb fawb pom tias astaxanthin hauv tib neeg lub hlwb los tsim cov immunoglobulins, hauv tib neeg lub cev astaxanthin noj rau 8 lub lis piam, cov theem astaxanthin hauv cov ntshav nce ntxiv, T hlwb thiab B hlwb nce ntxiv, DNA puas tsuaj txo qis, C-reactive protein txo qis heev.
Astaxanthin softgels, astaxanthin nyoos, siv lub hnub ci ntuj, dej lim lava thiab lub zog hnub ci los tsim cov astaxanthin ntshiab thiab noj qab haus huv, uas tuaj yeem pab txhim kho kev tiv thaiv kab mob, tiv thaiv kev pom kev thiab kev noj qab haus huv ntawm pob qij txha.
7) Txo Kev Qaug Zog
Ib txoj kev tshawb nrhiav 4 lub lis piam uas tsis tau muab tshuaj ntsuam xyuas, ob leeg dig muag, thiab tswj los ntawm placebo, pom tau tias astaxanthin ua rau lub hlwb qaug zog, ua rau cov plasma phosphatidylcholine hydroperoxide (PCOOH) tsis muaj zog thaum lub sijhawm ua haujlwm ntawm lub hlwb thiab lub cev. Qhov laj thawj yog vim li cas astaxanthin thiaj li ua haujlwm tiv thaiv kev laus thiab tiv thaiv kev o.
8) Kev tiv thaiv kab mob siab
Astaxanthin muaj cov teebmeem tiv thaiv thiab kho cov teeb meem kev noj qab haus huv xws li mob siab fibrosis, mob siab ischemia-reperfusion, thiab NAFLD. Astaxanthin tuaj yeem tswj ntau yam kev taw qhia, xws li txo JNK thiab ERK-1 kev ua haujlwm los txhim kho kev tiv thaiv insulin hauv siab, tiv thaiv PPAR-γ kev qhia kom txo cov rog hauv siab, thiab txo qis TGF-β1 / Smad3 kev qhia kom tiv thaiv HSCs kev ua haujlwm thiab mob siab fibrosis.
Cov xwm txheej ntawm cov cai hauv txhua lub tebchaws
Nyob rau hauv Suav teb,astaxanthin los ntawm qhov chaw ntawm cov algae liab zaj sawv tuaj yeem siv ua cov khoom noj tshiab hauv cov khoom noj dav dav (tshwj tsis yog cov khoom noj menyuam yaus), ntxiv rau, Tebchaws Meskas, Canada thiab Nyiv kuj tso cai rau astaxanthin siv rau hauv cov khoom noj.
Lub sijhawm tshaj tawm: Lub Kaum Ob Hlis-05-2024