Hloov Cov Neeg Siv Khoom Pom Zoo rau Kev Laus

Cov neeg siv khoom xav txog kev laus yog hloov zuj zus. Raws li cov neeg siv khoom lag luam qhia los ntawmCov Neeg Siv Khoom TshiabthiabCoefficient Capital, ntau tus neeg Amelikas tau tsom mus tsis yog rau kev ua neej nyob ntev xwb tab sis kuj tseem ua neej nyob noj qab haus huv.

Kev tshawb fawb xyoo 2024 los ntawm McKinsey tau qhia tias xyoo dhau los, 70% ntawm cov neeg siv khoom hauv Asmeskas thiab UK (thiab 85% hauv Suav teb) tau yuav ntau cov khoom thiab cov kev pabcuam txhawb kev noj qab haus huv thiab kev noj qab haus huv zoo piv rau xyoo dhau los. Qhov kev hloov pauv no qhia txog kev xav tau ntawm cov neeg siv khoom loj los tswj hwm lawv txoj kev noj qab haus huv.

Ntxiv thiab,Nutrition Business Journal's(NBJ) 2024 Longevity Report qhia tias txij li xyoo 2022, kev muag khoom loj hlob nyob rau hauv cov laus laus noj qab haus huv tau tsis tu ncua outpaced lub khw muag tshuaj. Hauv 2023, tag nrho cov kev lag luam tshuaj ntxiv tau nce los ntawm 4.4%, thaum cov laus noj qab haus huv tau ua tiav 5.5% kev loj hlob.NBJtej yaam num uas muag ntawmnoj qab nyob zoo aging supplements- nthuav tawm ntau yam xwm txheej tshwj xeeb subcategories - yuav dhau $ 1 nphom hauv 2024 thiab ncav cuag $ 1.04 nphom los ntawm 2026, sawv cev rau kev loj hlob ntawm 7.7%.
1.Cov neeg siv kev txhawj xeeb txog hnub nyoog txog cov teeb meem kev noj qab haus huv

IbNBJKev tshawb fawb tau ua nyob rau hauv 2024 tshawb nrhiav cov neeg siv khoom txhawj xeeb txog kev laus. Cov teeb meem tseem ceeb suav nrog:

Kev poob ntawm kev txav mus los (28%)
Alzheimer's disease lossis dementia (23%)
Kev tsis pom kev (23%)
Poob kev ywj pheej (19%)
Kev nyuaj siab los yog kev puas siab puas ntsws (19%)
Cov leeg nqaij lossis pob txha degeneration (19%)
Cov plaub hau poob (16%)
Insomnia (16%)

Image Source: NBJ

Thaum sivtshuaj ntxiv, kev tiv thaiv kab mob (35%) tau tshwm sim raws li lub hnub nyoog tseem ceeb tshaj plaws txog kev noj qab haus huv rau cov neeg siv khoom. Lwm yam tseem ceeb suav nrog kev noj qab haus huv ntawm plab thiab plab hnyuv (28%), kev noj qab haus huv pw tsaug zog (23%), plaub hau, tawv nqaij, thiab rau tes (22%), nqaij thiab pob qij txha (21%), mob plawv (19%), thiab kev zoo siab (19%).

Image Source: NBJ

2.Tsib Yam Tseem Ceeb Anti-Aging

1. Ergothioneine

Ergothioneine yog ib qho tshwm sim ntawm cov amino acid nrhiav tau nyob rau hauv 1909 los ntawm Charles Tanret thaum kawm ergot fungi. Nws tshwj xeeb thiol thiab thione tautomerism ntawm physiological pH muab nws tshwj xeeb antioxidant zog. Raws li cov ntaub ntawv los ntawm Bloomage Biotech, ergothioneine hauv Bioyouth ™-EGT qhia DPPH dawb radical scavenging kev ua si 14 npaug ntawm glutathione thiab 30 npaug ntawm coenzyme Q10.

Cov txiaj ntsig:

Daim tawv nqaij:Ergothioneine tiv thaiv UV-induced o, tiv thaiv DNA puas, thiab txhawb collagen synthesis thaum txo UV-txog collagen degradation.
Lub hlwb:Ergothioneine txhawb kev paub txog kev ua haujlwm, raws li pom los ntawm kev tshawb fawb soj ntsuam qhia paub txog kev paub zoo tom qab 12 lub lis piam ntxiv nrog nceb-derived ergothioneine.
Pw tsaug zog:Nws hla cov hlab ntsha-hlwb barrier, txo cov peroxynitrite tsim, thiab alleviates kev ntxhov siab, txhawb kev pw tsaug zog zoo.

2. Spermidine

Spermidine, ib feem ntawm tsev neeg polyamine, yog dav pom nyob rau hauv cov kab mob xws li kab mob, fungi, nroj tsuag, thiab tsiaj txhu. Cov khoom noj uas muaj xws li cov noob nplej, taum pauv, thiab huab tais oyster nceb. Cov qib spermidine poob qis nrog lub hnub nyoog, thiab nws cov teebmeem tiv thaiv kev laus raug ntaus nqi rau cov txheej txheem xws li autophagy induction, tiv thaiv kev ua haujlwm, thiab kev tswj hwm lipid metabolism.

Mechanisms:

Autophagy:Spermidine txhawb nqa cov txheej txheem rov ua dua tshiab ntawm tes, hais txog cov kab mob muaj hnub nyoog uas txuas rau autophagy tsis xws luag.
Anti-inflammatory: Nws txo cov pro-inflammatory cytokines thaum nce cov tshuaj tiv thaiv kab mob.
Lipid Metabolism:Spermidine muaj txiaj ntsig zoo cuam tshuam lipid synthesis thiab khaws cia, txhawb nqa cellular membrane fluidity thiab ntev.

3. Pyrroloquinoline Quinone (PQQ)

PQQ, ib qho dej-soluble quinone coenzyme, yog qhov tseem ceeb rau kev ua haujlwm mitochondrial. Nws tiv thaiv oxidative stress-induced mitochondrial kev puas tsuaj, txhawb mitochondrial biogenesis, thiab txhim kho paj hlwb loj hlob (NGF) ntau lawm. Cov kev tshawb fawb soj ntsuam qhia nws cov txiaj ntsig hauv kev txhim kho kev txawj ntse thiab cov ntshav ntws hauv cheeb tsam hauv cov neeg laus.

4. Phosphatidylserine (PS)

PS yog ib qho anionic phospholipid hauv eukaryotic cell membranes, qhov tseem ceeb rau cov txheej txheem xws li kev ua kom enzyme, cell apoptosis, thiab synaptic muaj nuj nqi. Muab los ntawm cov chaw xws li taum pauv, cov kab mob hauv hiav txwv, thiab paj noob hlis, PS txhawb nqa cov kab mob neurotransmitter, suav nrog acetylcholine thiab dopamine, uas txuas rau kev paub txog kev noj qab haus huv.

Daim ntawv thov:PS supplementation tau txuas rau kev txhim kho hauv cov xwm txheej xws li Alzheimer's, Parkinson's disease, thiab kev nyuaj siab, thiab muaj txiaj ntsig rau cov tib neeg uas muaj ADHD thiab cov kab mob autism spectrum.

5. Urolithin A(UA)

UA, ib qho metabolite ntawm ellagitannins pom nyob rau hauv cov khoom noj xws li pomegranates thiab walnuts, tau txheeb xyuas nyob rau hauv 2005. Kev tshawb fawb luam tawm nyob rau hauvNtuj Tshuaj(2016) tau pom tias UA txhawb nqa mitophagy, txuas ntxiv lub neej ntawm nematodes los ntawm 45%. Nws qhib txoj hauv kev mitochondrial autophagy, tshem tawm cov kab mob mitochondria puas thiab hais txog hnub nyoog txog kev ua haujlwm tsis zoo hauv cov leeg, hlab plawv, tiv thaiv kab mob, thiab tawv nqaij noj qab haus huv.

UA activated mitophagy pathway/Image source reference 1

Xaus

Raws li cov neeg tau txais kev pab ntau dua qhov tseem ceeb ntawm kev noj qab haus huv thiab kev ua neej ntev, qhov kev thov rau cov khoom xyaw tiv thaiv kev laus thiab cov tshuaj ntxiv tau nce ntxiv. Cov khoom xyaw tseem ceeb xws li ergothioneine, spermidine, PQQ, PS, thiab UA tab tom txhim kho txoj hauv kev rau kev daws teeb meem rau kev txhawj xeeb txog hnub nyoog. Cov kev tshawb fawb-rov qab cov ntsiab lus no qhia txog kev lag luam kev cog lus los txhawb kev noj qab haus huv, kev laus dua qub.